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        1. R&D Centers
        2. R&D Strength
        3. Clinical Research
        4. Pipeline

        The Company focuses on the research and development of new drugs. With its rich experience and expertise in drug R&D, the Company has successfully established the R&D and industrialization platforms for precision small molecule drugs and complex recombinant protein drugs, including bispecific and trispecific antibodies. The multiple platforms of the Company meet advanced international standards, and has lead to the development of a series of novel, small molecule and protein drugs, covering multiple therapeutic areas with unmet medical needs.

        The Company’s R&D pipeline includes drug candidates at multiple stages of development. The drugs in clinical development stage include Donafenib tabelets, Jaktinib tabelets, Jaktinib creams, Alkotinib capsules, recombinant human thrombin for topical use and recombinant human thyroid stimulating hormone for injection. The continual advancement of our technology platforms and the growing diversity of pipeline creates a unique competitive advantage, and provides a solid foundation for continued expansion of future revenue.

        GENSUN, a subsidiary of the Zelgen, develops the innovative protein immuno-therapeutics for the field of oncology. The current pipeline includes bispecific and trispecific antibodies that include, (1) inhibiting multiple immune checkpoint pathways; (2) blocking multiple key drug resistance pathways for current immune checkpoint treatments; (3) simultaneously blocking angiogenesis and immune checkpoint pathways; and (4) targeted immunotherapy that releases cytotoxic cells to directly kill tumor cells. Bispecific and trispecific antibodies block multiple tumor signaling pathways simultaneously, reducing the high cost incurred when treating patients with two or three different therapeutic antibodies. GENSUN’s product pipeline not only improves the efficacy and market opportunities of the current treatment options, but also brings greater pharmacoeconomic benefits.

         Chemical New Drug R&D Platform

        The R&D and industrialization platforms for precision small molecule drugs is the basis for the research and development of novel small molecule drugs. One of the Company’s key technologies is the world-leading drug stabilization technology. This platform takes advantage of the highly stable chemical-physical properties of deuterium-carbon bonds compared to hydrogen-carbon bonds, and has the potential to create new patented compounds that have higher efficacy, better pharmacokinetic properties, and/or lower incidence of adverse effects. This technology has effectively ensured success rate of new drugs for the Company. Additionally, the Company also actively discovers new small molecule drugs using structure-activity relationship screening, computer-aid simulation design, and new crystal form technology.

        澤璟

        Recombinant Protein R&D Platform

        Complex proteins, such as growth factors and antibodies, can be subjected to multiple post-translation modifications. Therefore, the manufacturing of those proteins in the living cells creates challenges for the process and quality control for protein-based therapeutics. Our CMC platform for complex recombinant proteins has allowed Zelgen to successfully develop recombinant human thrombin for topical use and recombinant human thyroid stimulating hormone for injection.  These products create unique, competitive position in the Chinese market.

        GENSUN has built its technical capabilities to develop first-in-class or best-in-class antibody drugs for tumor immunotherapy. GENSUN’s capabilities include the discovery of novel humanized therapeutic antibodies, the genetic engineering of complex bispecific and trispecific antibody molecules, in vitro and in vivo analysis, testing, screening, and identification of candidate drugs. This enables GENSUN to have capabilities of end-to-end discovery and optimization of protein therapeutic drugs that take advantage of high-potential targets and increase the chance of clinical and manufacturing success, as well as helping the Company to obtain the best candidate drugs and the global intellectual property rights. These novel antibody drugs can also be combined with the Company's novel small molecule targeted drugs to form highly promising combination therapeutic strategies. 

        RD 


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